The national innovation systems (NIS) development is characterized by many heterogeneous factors with non-obvious causal connections and an uncertain power of influence on the result. The situation is complicated by the turbulence of the environment caused by the processes of globalization and the formation of a new industry. Considering that country's innovation system is being transformed within the framework of certain supranational conditions and together with them, the paper proposes a scientific and practical toolkit for NIS regulation in terms of justifying a set of priority target regulators that can be effectively influenced in the context of all its components, taking into account the glocalization aspect - opportunities for optimizing local features and global trends.The scientific and methodological approach is based on the analysis of 136 world's economies in the context of the Quadruple helix model, which takes into account the co-evolutionary interaction of all NIS complexes. At the same time, the deductive method of generalization was used, when first, a cluster analysis is carried out on an expanded set of indicators, and then, based on the methods of genetic algorithms, ranking and Pareto-selection, the most significant indicators for regulation are selected without loss of representativeness of the sample.Based on the study results, four basic types of transnational innovation systems (TNIS) have been identified, to which, with one approximation or another, all national macroeconomics in the world can be attributed. It is proved that the motion vectors of each individual NIS, on the one hand, are different, on the other - can be significantly limited by the specificity of its TNIS type.On the Poland’s case two pools of regulatory indicators are identified, which are recommended for the formation of targets for the NIS development, taking into account its specificity and orientation to either a cluster leader or a world one. Precisely these pools must determine the imperatives that can be effectively influenced by the government within their functions and powers. By changes' modeling in the development vector of Poland's NIS is demonstrated the glocalization complexity in the innovation sphere. The main local reactions of countries to global challenges is summarized.The practical prospect of the study lies in the possibility of conducting variable analytical and predictive studies of the directions of innovative development of a particular country in the context of global and cluster trends.

innovation system; spiral of innovations; glocalization; cluster analysis; target regulators; development vector

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